AC Milan vs. Napoli odds, picks and predictions

AC Milan welcomes Napoli to San Siro Wednesday for the 1st leg of their UEFA Champions League quarterfinal. Kickoff is set for 3 p.m. ET. Below, we analyze BetMGM Sportsbook's lines around the AC Milan vs. Napoli odds , and make our best Champions League bets , picks and predictions.

AC Milan finished 2nd in Group E, winning 3 games, losing 2 and drawing 1. AC Milan scored 12 goals and allowed 7. It qualified for the Round of 16, where it took down Tottenham by a combined 1-0. Milan sits 4th in Serie A, the top Italian League. F Rafael Leao leads the club with 20 goals in 22 starts.

Napoli won Group A, going 5-1 with 20 goals and 6 against. Napoli is 1st in Serie A and 13-1-1 on the road in league play. Nigerian F Victor Osimhen leads Napoli with 21 goals in 22 starts. Napoli took down Eintracht Frankfurt by a combined 5-0 in the Round of 16.